Nanoparticle-cell interactions

Nanoparticles have important biomedical applications ranging from the treatment of human disease with gene therapy to understanding basic cellular functions with fluorescent probes. In all of these applications, nanoparticles come into contact with a complex mixture of extracellular proteins. The Payne Lab is interested in understanding how adsorption of proteins onto the surface of a nanoparticle alters the interaction of the nanoparticle with a cell. By understanding how nanoparticles interact with cells in a realistic biological environment, we will be able to design better nanoparticles for the treatment and detection of human disease.